The admin manual suggests to use fastcgi_request_buffering off for nginx configurations. However, this breaks in situations where the Content-Length header is not set (e.g. streaming upload on WebDAV, like DAVx⁵ does).
Note that PHP does not plan to change php-fpm's behavior, as the (ancient, unmaintained) FastCGI spec requires the Content-Length header: https://bugs.php.net/bug.php?id=51191
nginx does not care, because it works with enabled buffering: https://trac.nginx.org/nginx/ticket/2287
Symptom analysis here (TL;DR: bigger uploads using DAVx⁵ will always fail): seedvault-app/seedvault#505
My suggestion is to enable fastcgi_request_buffering to get this use case to work, but I don't know if anything else depends on disabled buffering.