diff --git a/shell/common/persistent_cache_unittests.cc b/shell/common/persistent_cache_unittests.cc
index 9a1daf2a71c02..4fcb8cf44605f 100644
--- a/shell/common/persistent_cache_unittests.cc
+++ b/shell/common/persistent_cache_unittests.cc
@@ -41,6 +41,11 @@ static void WaitForRaster(Shell* shell) {
 }
 
 TEST_F(PersistentCacheTest, CacheSkSLWorks) {
+#if defined(WINUWP)
+  // TODO(cbracken): Re-enable. https://github.com/flutter/flutter/issues/90481
+  GTEST_SKIP() << "Skipped on WinUWP; requires vm service sandboxing fix";
+#endif  // defined(WINUWP)
+
   // Create a temp dir to store the persistent cache
   fml::ScopedTemporaryDirectory dir;
   PersistentCache::SetCacheDirectoryPath(dir.path());
@@ -204,6 +209,11 @@ static void CheckTwoSkSLsAreLoaded() {
 }
 
 TEST_F(PersistentCacheTest, CanLoadSkSLsFromAsset) {
+#if defined(WINUWP)
+  // TODO(cbracken): Re-enable. https://github.com/flutter/flutter/issues/90481
+  GTEST_SKIP() << "Skipped on WinUWP; requires filesystem sandboxing fix";
+#endif  // defined(WINUWP)
+
   // Avoid polluting unit tests output by hiding INFO level logging.
   fml::LogSettings warning_only = {fml::LOG_WARNING};
   fml::ScopedSetLogSettings scoped_set_log_settings(warning_only);
@@ -268,6 +278,11 @@ TEST_F(PersistentCacheTest, CanLoadSkSLsFromAsset) {
 }
 
 TEST_F(PersistentCacheTest, CanRemoveOldPersistentCache) {
+#if defined(WINUWP)
+  // TODO(cbracken): Re-enable. https://github.com/flutter/flutter/issues/90481
+  GTEST_SKIP() << "Skipped on WinUWP; requires filesystem sandboxing fix";
+#endif  // defined(WINUWP)
+
   fml::ScopedTemporaryDirectory base_dir;
   ASSERT_TRUE(base_dir.fd().is_valid());
 
@@ -298,6 +313,11 @@ TEST_F(PersistentCacheTest, CanRemoveOldPersistentCache) {
 }
 
 TEST_F(PersistentCacheTest, CanPurgePersistentCache) {
+#if defined(WINUWP)
+  // TODO(cbracken): Re-enable. https://github.com/flutter/flutter/issues/90481
+  GTEST_SKIP() << "Skipped on WinUWP; requires filesystem sandboxing fix";
+#endif  // defined(WINUWP)
+
   fml::ScopedTemporaryDirectory base_dir;
   ASSERT_TRUE(base_dir.fd().is_valid());
   auto cache_dir = fml::CreateDirectory(
@@ -330,6 +350,11 @@ TEST_F(PersistentCacheTest, CanPurgePersistentCache) {
 }
 
 TEST_F(PersistentCacheTest, PurgeAllowsFutureSkSLCache) {
+#if defined(WINUWP)
+  // TODO(cbracken): Re-enable. https://github.com/flutter/flutter/issues/90481
+  GTEST_SKIP() << "Skipped on WinUWP; requires filesystem sandboxing fix";
+#endif  // defined(WINUWP)
+
   sk_sp<SkData> shader_key = SkData::MakeWithCString("key");
   sk_sp<SkData> shader_value = SkData::MakeWithCString("value");
   std::string shader_filename = PersistentCache::SkKeyToFilePath(*shader_key);
diff --git a/shell/common/shell_unittests.cc b/shell/common/shell_unittests.cc
index b3b5de6d66d3c..2f16650f80a2d 100644
--- a/shell/common/shell_unittests.cc
+++ b/shell/common/shell_unittests.cc
@@ -440,6 +440,11 @@ TEST_F(ShellTest, LastEntrypoint) {
 }
 
 TEST_F(ShellTest, DisallowedDartVMFlag) {
+#if defined(WINUWP)
+  // TODO(cbracken): Re-enable. https://github.com/flutter/flutter/issues/90481
+  GTEST_SKIP() << "Skipped on WinUWP; requires fix";
+#endif  // defined(WINUWP)
+
   // Run this test in a thread-safe manner, otherwise gtest will complain.
   ::testing::FLAGS_gtest_death_test_style = "threadsafe";
 
@@ -454,6 +459,10 @@ TEST_F(ShellTest, DisallowedDartVMFlag) {
 }
 
 TEST_F(ShellTest, AllowedDartVMFlag) {
+#if defined(WINUWP)
+  // TODO(cbracken): Re-enable. https://github.com/flutter/flutter/issues/90481
+  GTEST_SKIP() << "Skipped on WinUWP; requires fix";
+#endif  // defined(WINUWP)
   std::vector<const char*> flags = {
       "--enable-isolate-groups",
       "--no-enable-isolate-groups",
@@ -466,6 +475,7 @@ TEST_F(ShellTest, AllowedDartVMFlag) {
     flags.push_back("--enable_mirrors");
   }
 #endif
+
   TestDartVmFlags(flags);
 }
 
@@ -756,6 +766,10 @@ TEST_F(ShellTest,
        OnPlatformViewDestroyDisablesThreadMerger
 #endif
 ) {
+#if defined(WINUWP)
+  // TODO(cbracken): Re-enable. https://github.com/flutter/flutter/issues/90481
+  GTEST_SKIP() << "Skipped on WinUWP. Not yet implemented";
+#endif  // defined(WINUWP)
   auto settings = CreateSettingsForFixture();
   fml::RefPtr<fml::RasterThreadMerger> raster_thread_merger;
   auto end_frame_callback =
@@ -1336,6 +1350,11 @@ TEST_F(ShellTest, ReloadSystemFonts) {
 }
 
 TEST_F(ShellTest, WaitForFirstFrame) {
+#if defined(WINUWP)
+  // TODO(cbracken): Re-enable. https://github.com/flutter/flutter/issues/90481
+  GTEST_SKIP() << "Skipped on WinUWP; requires fix";
+#endif  // defined(WINUWP)
+
   auto settings = CreateSettingsForFixture();
   std::unique_ptr<Shell> shell = CreateShell(settings);
 
@@ -1391,6 +1410,11 @@ TEST_F(ShellTest, WaitForFirstFrameTimeout) {
 }
 
 TEST_F(ShellTest, WaitForFirstFrameMultiple) {
+#if defined(WINUWP)
+  // TODO(cbracken): Re-enable. https://github.com/flutter/flutter/issues/90481
+  GTEST_SKIP() << "Skipped on WinUWP; requires threading fix";
+#endif  // defined(WINUWP)
+
   auto settings = CreateSettingsForFixture();
   std::unique_ptr<Shell> shell = CreateShell(settings);
 
@@ -1415,6 +1439,11 @@ TEST_F(ShellTest, WaitForFirstFrameMultiple) {
 /// Makes sure that WaitForFirstFrame works if we rendered a frame with the
 /// single-thread setup.
 TEST_F(ShellTest, WaitForFirstFrameInlined) {
+#if defined(WINUWP)
+  // TODO(cbracken): Re-enable. https://github.com/flutter/flutter/issues/90481
+  GTEST_SKIP() << "Skipped on WinUWP; requires threading fix";
+#endif  // defined(WINUWP)
+
   Settings settings = CreateSettingsForFixture();
   auto task_runner = CreateNewThread();
   TaskRunners task_runners("test", task_runner, task_runner, task_runner,
@@ -2001,6 +2030,11 @@ TEST_F(ShellTest, CanRegisterImageDecoders) {
 }
 
 TEST_F(ShellTest, OnServiceProtocolGetSkSLsWorks) {
+#if defined(WINUWP)
+  // TODO(cbracken): Re-enable. https://github.com/flutter/flutter/issues/90481
+  GTEST_SKIP() << "Skipped on WinUWP; requires vm service sandboxing fix";
+#endif  // defined(WINUWP)
+
   fml::ScopedTemporaryDirectory base_dir;
   ASSERT_TRUE(base_dir.fd().is_valid());
   PersistentCache::SetCacheDirectoryPath(base_dir.path());
@@ -2432,6 +2466,11 @@ TEST_F(ShellTest, IgnoresInvalidMetrics) {
 }
 
 TEST_F(ShellTest, OnServiceProtocolSetAssetBundlePathWorks) {
+#if defined(WINUWP)
+  // TODO(cbracken): Re-enable. https://github.com/flutter/flutter/issues/90481
+  GTEST_SKIP() << "Skipped on WinUWP; requires vm service sandboxing fix";
+#endif  // defined(WINUWP)
+
   Settings settings = CreateSettingsForFixture();
   std::unique_ptr<Shell> shell = CreateShell(settings);
   RunConfiguration configuration =
@@ -2504,6 +2543,11 @@ TEST_F(ShellTest, EngineRootIsolateLaunchesDontTakeVMDataSettings) {
 }
 
 TEST_F(ShellTest, AssetManagerSingle) {
+#if defined(WINUWP)
+  // TODO(cbracken): Re-enable. https://github.com/flutter/flutter/issues/90481
+  GTEST_SKIP() << "Skipped on WinUWP; requires filesystem sandboxing fix";
+#endif  // defined(WINUWP)
+
   fml::ScopedTemporaryDirectory asset_dir;
   fml::UniqueFD asset_dir_fd = fml::OpenDirectory(
       asset_dir.path().c_str(), false, fml::FilePermission::kRead);
@@ -2529,6 +2573,11 @@ TEST_F(ShellTest, AssetManagerSingle) {
 }
 
 TEST_F(ShellTest, AssetManagerMulti) {
+#if defined(WINUWP)
+  // TODO(cbracken): Re-enable. https://github.com/flutter/flutter/issues/90481
+  GTEST_SKIP() << "Skipped on WinUWP; requires filesystem sandboxing fix";
+#endif  // defined(WINUWP)
+
   fml::ScopedTemporaryDirectory asset_dir;
   fml::UniqueFD asset_dir_fd = fml::OpenDirectory(
       asset_dir.path().c_str(), false, fml::FilePermission::kRead);