diff --git a/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/OffsetOfTests.cs b/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/OffsetOfTests.cs
index 00fc49e78c552a..3781d521678c86 100644
--- a/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/OffsetOfTests.cs
+++ b/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/OffsetOfTests.cs
@@ -5,6 +5,7 @@
 using System.Globalization;
 using System.Reflection;
 using System.Reflection.Emit;
+using Microsoft.DotNet.XUnitExtensions;
 using Xunit;
 
 namespace System.Runtime.InteropServices.Tests
@@ -33,6 +34,7 @@ public void OffsetOf_ClassWithSequentialLayout_ReturnsExpected()
         }
 
         [Fact]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49872", typeof(PlatformDetection), nameof(PlatformDetection.IsAndroid), nameof(PlatformDetection.Is32BitProcess))]
         public void OffsetOf_ExplicitLayout_ReturnsExpected()
         {
             Type t = typeof(ExplicitLayoutTest);
@@ -105,6 +107,7 @@ public void OffsetOf_ValidField_ReturnsExpected()
         }
 
         [Fact]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49872", typeof(PlatformDetection), nameof(PlatformDetection.IsAndroid), nameof(PlatformDetection.Is32BitProcess))]
         public void OffsetOf_Decimal_ReturnsExpected()
         {
             Type t = typeof(FieldAlignmentTest_Decimal);