diff --git a/src/libraries/System.IO.Compression.Brotli/tests/AssemblyInfo.cs b/src/libraries/System.IO.Compression.Brotli/tests/AssemblyInfo.cs
new file mode 100644
index 00000000000000..1038dc251cb5b3
--- /dev/null
+++ b/src/libraries/System.IO.Compression.Brotli/tests/AssemblyInfo.cs
@@ -0,0 +1,7 @@
+// Licensed to the .NET Foundation under one or more agreements.
+// The .NET Foundation licenses this file to you under the MIT license.
+
+using System;
+using Xunit;
+
+[assembly: SkipOnMono("System.IO.Compression.Brotli is not supported on Browser", TestPlatforms.Browser)]
diff --git a/src/libraries/System.IO.Compression.Brotli/tests/System.IO.Compression.Brotli.Tests.csproj b/src/libraries/System.IO.Compression.Brotli/tests/System.IO.Compression.Brotli.Tests.csproj
index d45b0875d55af0..31950ce9235bb9 100644
--- a/src/libraries/System.IO.Compression.Brotli/tests/System.IO.Compression.Brotli.Tests.csproj
+++ b/src/libraries/System.IO.Compression.Brotli/tests/System.IO.Compression.Brotli.Tests.csproj
@@ -1,8 +1,9 @@
 <Project Sdk="Microsoft.NET.Sdk">
   <PropertyGroup>
-    <TargetFrameworks>$(NetCoreAppCurrent)-Windows_NT;$(NetCoreAppCurrent)-Unix</TargetFrameworks>
+    <TargetFrameworks>$(NetCoreAppCurrent)-Windows_NT;$(NetCoreAppCurrent)-Unix;$(NetCoreAppCurrent)-Browser</TargetFrameworks>
   </PropertyGroup>
   <ItemGroup>
+    <Compile Include="AssemblyInfo.cs" />
     <Compile Include="BrotliEncoderTests.cs" />
     <Compile Include="BrotliGoogleTestData.cs" />
     <Compile Include="CompressionStreamUnitTests.Brotli.cs" />
diff --git a/src/libraries/tests.proj b/src/libraries/tests.proj
index 540ec8a56987cf..402a099f131827 100644
--- a/src/libraries/tests.proj
+++ b/src/libraries/tests.proj
@@ -47,12 +47,10 @@
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Globalization.Calendars\tests\System.Globalization.Calendars.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Globalization.Extensions\tests\System.Globalization.Extensions.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Globalization\tests\System.Globalization.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.Compression.Brotli\tests\System.IO.Compression.Brotli.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.Compression.ZipFile\tests\System.IO.Compression.ZipFile.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.Compression\tests\System.IO.Compression.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.FileSystem.DriveInfo\tests\System.IO.FileSystem.DriveInfo.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.FileSystem\tests\System.IO.FileSystem.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.IsolatedStorage\tests\System.IO.IsolatedStorage.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.MemoryMappedFiles\tests\System.IO.MemoryMappedFiles.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.Packaging\tests\System.IO.Packaging.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.Pipes\tests\System.IO.Pipes.Tests.csproj" />